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活性依賴的神經(jīng)保護肽抗體
  • 產(chǎn)品貨號：
    BN40204R
  • 中文名稱：
    活性依賴的神經(jīng)保護肽抗體
  • 英文名稱：
    Rabbit anti-ADNP Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產(chǎn)品規(guī)格

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  • BN40204R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Mouse,Rat(predicted:Human,Chicken,Dog,Cow) 推薦應(yīng)用：WB,IHC-P,IHC-F,IF,ELISA

  • BN40204R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Mouse,Rat(predicted:Human,Chicken,Dog,Cow) 推薦應(yīng)用：WB,IHC-P,IHC-F,IF,ELISA

產(chǎn)品描述

英文名稱ADNP
中文名稱活性依賴的神經(jīng)保護肽抗體
別    名Activity dependent neuroprotective protein; Activity dependent neuroprotector; NAP; KIAA0784


研究領(lǐng)域細胞生物  神經(jīng)生物學(xué)  細胞凋亡  轉(zhuǎn)錄調(diào)節(jié)因子  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Mouse, Rat,  (predicted: Human, Chicken, Dog, Cow, )
產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量114kDa
細胞定位細胞核 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human ADNP:331-400/1102 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹The activity dependent neuroprotective protein (ADNP) gene is frequently amplified in many neoplasias, including breast, bladder, ovarian, pancreatic, and colon cancers. ADNP mRNA is abundantly expressed in distinct normal tissues, and high expression levels were encountered in malignant cells. ADNP is implicated in maintaining cell survival, perhaps through modulation of p53. The encoded protein contains one homeobox and nine zinc finger domains, suggesting that it functions as a transcription factor.

Function:
Potential transcription factor. May mediate some of the neuroprotective peptide VIP-associated effects involving normal growth and cancer proliferation.

Subcellular Location:
Nucleus (Potential).

Tissue Specificity:
Widely expressed. Strong expression in heart, skeletal muscle, kidney and placenta. In brain, expression is stronger in the cerebellum and cortex regions. No expression detected in the colon. Strong increase of expression in colon and breast cancer tissues.

Similarity:
Contains 9 C2H2-type zinc fingers.
Contains 1 homeobox DNA-binding domain.

SWISS:
Q9H2P0

Gene ID:
23394

Database links:

Entrez Gene: 23394 Human

Omim: 611386 Human

SwissProt: Q9H2P0 Human

Unigene: 570355 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

是一個潛在的轉(zhuǎn)錄調(diào)節(jié)因子，參與正常細胞與腫瘤細胞的增殖調(diào)控。
廣泛分布于大腦、小腦等組織，在肺、腎、小腸以及睪丸等組織也有微弱的表達。對體外培養(yǎng)的glia缺失神經(jīng)元細胞有保護作用.