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細(xì)胞外基質(zhì)蛋白1抗體
  • 產(chǎn)品貨號(hào)：
    BN40217R
  • 中文名稱：
    細(xì)胞外基質(zhì)蛋白1抗體
  • 英文名稱：
    Rabbit anti-ECM1 Polyclonal antibody
  • 品牌：
    Biorigin

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  • BN40217R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Human,Mouse,Rat(predicted:Dog,Cow) 推薦應(yīng)用：WB,IHC-P,IHC-F,IF,ELISA

  • BN40217R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Human,Mouse,Rat(predicted:Dog,Cow) 推薦應(yīng)用：WB,IHC-P,IHC-F,IF,ELISA

產(chǎn)品描述

英文名稱ECM1
中文名稱細(xì)胞外基質(zhì)蛋白1抗體
別    名Secretory Component Glycoprotein; ECM 1; Ecm1; ECM1_HUMAN; Extracellular matrix protein 1; Secretory component p85.  
研究領(lǐng)域腫瘤  細(xì)胞生物  免疫學(xué)  細(xì)胞膜受體  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Human, Mouse,  (predicted: Rat, Dog, Cow, )
產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量59kDa
細(xì)胞定位分泌型蛋白 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human ECM1:488-567/567 
亞    型IgG
純化方法affinity purified by Protein A
儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹Extracellular matrix protein 1 (ECM1) This family consists of several eukaryotic extracellular matrix protein 1 (ECM1) sequences. ECM1 has been shown to regulate endochondral bone formation, stimulate the proliferation of endothelial cells and induce angiogenesis. Mutations in the ECM1 gene can cause lipoid proteinosis, a disorder which causes generalised thickening of skin, mucosae and certain viscera. Classical features include beaded eyelid papules and laryngeal infiltration leading to hoarseness.

Function:
Involved in endochondral bone formation as negative regulator of bone mineralization. Stimulates the proliferation of endothelial cells and promotes angiogenesis. Inhibits MMP9 proteolytic activity.

Subunit:
Interacts (via C-terminus) with HSPG2 (via C-terminus). Interacts with EFEMP1/FBLN3 and LAMB3. Interacts with MMP9.

Subcellular Location:
Secreted, extracellular space, extracellular matrix.

Tissue Specificity:
Expressed in breast cancer tissues. Little or no expression observed in normal breast tissues. Expressed in skin; wide expression is observed throughout the dermis with minimal expression in the epidermis.

DISEASE:
Lipoid proteinosis (LiP) [MIM:247100]: Rare autosomal recessive disorder characterized by generalized thickening of skin, mucosae and certain viscera. Classical features include beaded eyelid papules and laryngeal infiltration leading to hoarseness. Histologically, there is widespread deposition of hyaline material and disruption/reduplication of basement membrane. Note=The disease is caused by mutations affecting the gene represented in this entry.

SWISS:
Q61508

Gene ID:
1893

Database links:

Entrez Gene: 1893 Human

Entrez Gene: 116662 Rat

GenBank: NP_073155 Human

Omim: 602201 Human

SwissProt: Q16610 Human

SwissProt: Q62894 Rat

Unigene: 81071 Human

Unigene: 97792 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

ECM1是一種分泌性糖蛋白，ECM1可促進(jìn)血管內(nèi)皮細(xì)胞的增殖和血管的生成, 經(jīng)研究發(fā)現(xiàn)，ECM1的表達(dá)可能與腫瘤及腫瘤的轉(zhuǎn)移有關(guān)聯(lián), 而目前在多種腫瘤的研究中也已確認(rèn)細(xì)胞外基質(zhì)與腫瘤的發(fā)生、發(fā)展及轉(zhuǎn)移等有密切的關(guān)系, ECM1是目前腫瘤研究的熱點(diǎn)。