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神經(jīng)細胞粘附分子2抗體
  • 產(chǎn)品貨號：
    BN40284R
  • 中文名稱：
    神經(jīng)細胞粘附分子2抗體
  • 英文名稱：
    Rabbit anti-NCAM2 Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產(chǎn)品規(guī)格

    售價

    備注

  • BN40284R-100ul

    100ul

    ￥2360.00

    交叉反應：Human(predicted:Mouse,Rat,Rabbit) 推薦應用：Flow-Cyt,ELISA

  • BN40284R-200ul

    200ul

    ￥3490.00

    交叉反應：Human(predicted:Mouse,Rat,Rabbit) 推薦應用：Flow-Cyt,ELISA

產(chǎn)品描述

英文名稱NCAM2
中文名稱神經(jīng)細胞粘附分子2抗體
別    名N CAM 2; N CAM 21; N CAM2; N CAM21; N-CAM-2; NCAM 2; NCAM 21; NCAM-2; Ncam2; NCAM2_HUMAN; NCAM21; Neural cell adhesion molecule 2; OCAM GPI; R4B12; RB 8 neural cell adhesion molecule; RB8 neural cell adhesion molecule; RNCAM.  
研究領域神經(jīng)生物學  信號轉(zhuǎn)導  細胞粘附分子  細胞膜蛋白  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應Human,  (predicted: Mouse, Rat, Rabbit, )
產(chǎn)品應用ELISA=1:5000-10000 Flow-Cyt=3ug/test 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量91kDa
細胞定位細胞膜 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human NCAM2:51-150/837 <Extracellular>
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹NCAM2 is an 837 amino acid protein encoded by the human gene NCAM2. NCAM2 contains five immunoglobulin-like domains, two Fibronectin type III domains, a transmembrane domain and a cytoplasmic domain. The gene is expressed most strongly in human adult and fetal brain. NCAM2 is a member of the neural cell adhesion molecule (NCAM) family. NCAMs are closely related cell surface glycoproteins involved in cell to cell interactions during growth and are thought to play an important role in embryogenesis and development. NCAM2 is a considered a good candidate for involvement in certain Down syndrome phenotypes because a slight overexpression of NCAMs increases many-fold the homotypic adhesion properties of cells. Stat5 regulates NCAM2 in vivo by binding to the NCAM2 intron in the NKL natural killer cell line; this binding is induced by cytokines that activate Stat5. Neither Stat1 nor Stat3 bind to this region, despite sharing a consensus binding sequence with Stat5.

Function:
May play important roles in selective fasciculation and zone-to-zone projection of the primary olfactory axons.

Subunit:
Contains 2 fibronectin type-III domains. Contains 5 Ig-like C2-type (immunoglobulin-like) domains.

Subcellular Location:
Cell membrane.

Tissue Specificity:
Expressed most strongly in adult and fetal brain.

Similarity:
Contains 2 fibronectin type-III domains.
Contains 5 Ig-like C2-type (immunoglobulin-like) domains.

SWISS:
O15394

Gene ID:
4685

Database links:

Entrez Gene: 4685 Human

Entrez Gene: 17968 Mouse

Entrez Gene: 288280 Rat

Omim: 602040 Human

SwissProt: O15394 Human

SwissProt: O35136 Mouse

Unigene: 473450 Human

Unigene: 433941 Mouse

Unigene: 138756 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
















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