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少突膠質(zhì)細胞髓鞘相關(guān)蛋白抗體
  • 產(chǎn)品貨號：
    BN40287R
  • 中文名稱：
    少突膠質(zhì)細胞髓鞘相關(guān)蛋白抗體
  • 英文名稱：
    Rabbit anti-MOBP Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產(chǎn)品規(guī)格

    售價

    備注

  • BN40287R-100ul

    100ul

    ￥2360.00

    交叉反應：Mouse,Rat(predicted:Human,Dog,Pig,Cow,Horse,Sheep) 推薦應用：WB,IHC-P,IHC-F,ICC,IF,ELISA

  • BN40287R-200ul

    200ul

    ￥3490.00

    交叉反應：Mouse,Rat(predicted:Human,Dog,Pig,Cow,Horse,Sheep) 推薦應用：WB,IHC-P,IHC-F,ICC,IF,ELISA

產(chǎn)品描述

英文名稱MOBP
中文名稱少突膠質(zhì)細胞髓鞘相關(guān)蛋白抗體
別    名MGC87379; Myelin associated oligodendrocyte basic protein; MOBP_HUMAN.  
研究領(lǐng)域細胞生物  神經(jīng)生物學  細胞類型標志物  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應Mouse, Rat,  (predicted: Human, Dog, Pig, Cow, Horse, Sheep, )
產(chǎn)品應用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量21kDa
細胞定位細胞漿 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human MOBP:7-90/183 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹The gene encoding MOBP a member of the central nervous system myelin-constituting proteins, maps to chromosome 3p22.2. MOBP has many splice variants that share a 68 amino acid N-terminal domain. MOBP-71, MOBP-81A, MOBP-99, and MOBP-169 are MOBP splice variants that contain exon 8b, which is similar to myelin basic protein (MBP) mRNA RTS, however MOBP-69, MOBP-81B, and MOBP-170 lack this exon. The splice variants that contain exon 8b are expressed in myelin, while those lacking exon 8b are retained in the oligodendrocyte soma. Exon 8b-containing variants are directed to sites of myelin sheath assembly by exon 8b, where they play a structural role in myelin formation. Splice variants lacking exon 8b likely play a cellular and/or regulatory role. MOBP is implicated in multiple sclerosis (MS), a human demyelinating disease, and in allergic encephalomyelitis in rodents.

Function:
MOBP (Myelin-associated oligodendrocytic basic protein) is abundantly expressed specifically in oligodendrocytes and is the third most abundant protein in CNS myelin. MOBP is present in the major dense line of CNS myelin suggesting a role in the compaction or stabilization of myelin.

Subcellular Location:
Cytoplasm, perinuclear region. Note=Present in the major dense line of CNS myelin (By similarity).

SWISS:
Q13875

Gene ID:
4336

Database links:

Entrez Gene: 4336 Human

Entrez Gene: 17433 Mouse

Entrez Gene: 25037 Rat

Omim: 600948 Human

SwissProt: Q13875 Human

SwissProt: Q9D2P8 Mouse

SwissProt: Q63327 Rat

Unigene: 121333 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.













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