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磷酸化C端結(jié)合蛋白1抗體
  • 產(chǎn)品貨號：
    BN40296R
  • 中文名稱：
    磷酸化C端結(jié)合蛋白1抗體
  • 英文名稱：
    Rabbit anti-phospho-CTBP1 (Ser422) Polyclonal antibody
  • 品牌：
    Biorigin

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  • BN40296R-100ul

    100ul

    ￥2470.00

    交叉反應(yīng)：Rat(predicted:Human,Mouse,Chicken,Dog,Cow,Horse,Danio rerio) 推薦應(yīng)用：IHC-P,IHC-F,ICC,IF,ELISA

產(chǎn)品描述

英文名稱phospho-CTBP1 (Ser422)
中文名稱磷酸化C端結(jié)合蛋白1抗體
別    名CTBP1 (phospho Ser422); p-CTBP1 (Ser422); CtBP1 (phospho S422); BARS; C terminal binding protein 1; CTBP; CTBP1; MGC104684; CTBP1_HUMAN; C-terminal-binding protein 1; CtBP1.  
產(chǎn)品類型磷酸化抗體 
研究領(lǐng)域腫瘤  細(xì)胞生物  信號轉(zhuǎn)導(dǎo)  細(xì)胞周期蛋白  轉(zhuǎn)錄調(diào)節(jié)因子  細(xì)菌及病毒  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Rat,  (predicted: Human, Mouse, Chicken, Dog, Cow, Horse, Danio rerio)
產(chǎn)品應(yīng)用ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量49kDa
細(xì)胞定位細(xì)胞核 細(xì)胞漿 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthesised phosphopeptide derived from human CTBP1 around the phosphorylation site of Ser422:AP(p-S)PG 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹CtBP1 associates in complexes with histone deacetylases (HDAC), the G9a histone methyltransferase, and LSD1 histone demethylase illustrating its role in transcriptional repression. Through its association with centrosomes, CtBP1 appears to also play a role in mitosis and Golgi complex organization.

Function:
Involved in controlling the equilibrium between tubular and stacked structures in the Golgi complex. Functions in brown adipose tissue (BAT) differentiation. Corepressor targeting diverse transcription regulators such as GLIS2. Has dehydrogenase activity.

Subunit:
Homo- or heterodimer. Heterodimer with CTBP2. Interacts with PRDM16; the interaction represses white adipose tissue (WAT)-specific genes expression. Interacts with GLIS2, FOXP2, HDAC4, HDAC5, HDAC9 and ZNF217 (By similarity). Interacts with adenovirus E1A protein (via its C-terminus); the interaction disrupts the interaction of CTBP1 with RBBP8. Interacts with Epstein-Barr virus EBNA3 and EBNA6. Interacts with ELK3 (via its PXDLS motif). Interacts with RBBP8 (via its PXDLS motif); the interaction is disrupted by binding to adenovirus E1A. Interacts with FOXP1, HIPK2, PNN, NRIP1, MECOM, ZNF366, ZFHX1B and WIZ. Interaction with SATB1 (non-acetylated form); the interaction stabilizes its attachment to DNA and promotes transcription repression.

Subcellular Location:
Cytoplasm. Nucleus.

Post-translational modifications:
The level of phosphorylation appears to be regulated during the cell cycle. Phosphorylation by HIPK2 on Ser-422 induces proteasomal degradation.
ADP-ribosylated; when cells are exposed to brefeldin A.
Sumoylation on Lys-428 is promoted by the E3 SUMO-protein ligase CBX4.

Similarity:
Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

SWISS:
Q13363

Gene ID:
1487

Database links:

Entrez Gene: 1487 Human

Entrez Gene: 13016 Mouse

Entrez Gene: 29382 Rat

Omim: 602618 Human

SwissProt: Q13363 Human

SwissProt: O88712 Mouse

SwissProt: Q9Z2F5 Rat

Unigene: 208597 Human

Unigene: 594321 Human

Unigene: 7286 Mouse

Unigene: 3946 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.