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腦特異性多肽蛋白19抗體
  • 產(chǎn)品貨號(hào)：
    BN40302R
  • 中文名稱：
    腦特異性多肽蛋白19抗體
  • 英文名稱：
    Rabbit anti-PCP4 Polyclonal antibody
  • 品牌：
    Biorigin

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  • BN40302R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Mouse,Rat(predicted:Human,Cow,Sheep) 推薦應(yīng)用：IHC-P,IHC-F,ICC,IF,ELISA

  • BN40302R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Mouse,Rat(predicted:Human,Cow,Sheep) 推薦應(yīng)用：IHC-P,IHC-F,ICC,IF,ELISA

產(chǎn)品描述

英文名稱PCP4
中文名稱腦特異性多肽蛋白19抗體
別    名Brain specific antigen PCP 4; Brain specific polypeptide PEP 19; Brain specific polypeptide PEP19; PEP19; Purkinje cell protein 4; PCP-4; PCP4_HUMAN; PEP-19.  
研究領(lǐng)域細(xì)胞生物  神經(jīng)生物學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  激酶和磷酸酶  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Mouse, Rat,  (predicted: Human, Cow, Sheep, )
產(chǎn)品應(yīng)用ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量7kDa
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human PCP4:21-62/62 
亞    型IgG
純化方法affinity purified by Protein A
儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹PCP-4 is a calmodulin (CaM) regulatory protein that is highly expressed in neuronal cells. Through its IQ motif, PCP-4 mediates both the calcium-dependent binding properties of CaM and the rates of association and dissociation of calcium from the C-terminal domain of CaM. The IQ motif contains a serine residue which can be phosphorylated by all isoforms of protein kinase C (PKC). PCP-4 is implicated in uterine leiomyomas, as well as in neurodegenerative disorders such as Alzheimer’s disease and Huntington's disease. Additionally, overexpression of PCP-4 is thought to play a role in cerebellar hypoplasia, a key feature of Down syndrome.

Function:
Probable regulator of calmodulin signaling.

Subunit:
Binds to both calcium-free and calcium activated calmodulin, affinity for calcium-bound form is 50-fold greater.

Similarity:
Belongs to the PCP4 family.
Contains 1 IQ domain.

SWISS:
P48539

Gene ID:
5121

Database links:

Entrez Gene: 5121 Human

Entrez Gene: 18546 Mouse

Entrez Gene: 25510 Rat

Omim: 601629 Human

SwissProt: P48539 Human

SwissProt: P63054 Mouse

SwissProt: P63055 Rat

Unigene: 80296 Human

Unigene: 5023 Mouse

Unigene: 9736 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications