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BN40311R-100ul
100ul
￥2360.00
交叉反應(yīng)：Mouse,Rat(predicted:Human,Chicken,Rabbit) 推薦應(yīng)用：WB,IHC-P,ELISA
BN40311R-200ul
200ul
￥3490.00
交叉反應(yīng)：Mouse,Rat(predicted:Human,Chicken,Rabbit) 推薦應(yīng)用：WB,IHC-P,ELISA
產(chǎn)品描述
| 英文名稱 | Ctip1 |
| 中文名稱 | B淋巴細(xì)胞白血病/淋巴瘤11/鋅指蛋白856抗體 |
| 別 名 | BCL-11A; B cell CLL/lymphoma 11A (zinc finger protein); B cell CLL/lymphoma 11A (zinc finger protein) isoform 2; B cell CLL/lymphoma 11A; B cell lymphoma/leukaemia 11A; B-cell CLL/lymphoma 11A; B-cell lymphoma/leukemia 11A; BC11A_HUMAN; BCL 11A; BCL-11A; BCL11A; BCL11A B cell CLL/lymphoma 11A (zinc finger protein) isoform 1; BCL11A L; BCL11A S; BCL11A XL; BCL11AL; BCL11AS; BCL11AXL; C2H2 type zinc finger protein; COUP TF interacting protein 1; COUP-TF-interacting protein 1; Ctip 1; CTIP1; Ecotropic viral integration site 9; Ecotropic viral integration site 9 homolog; Ecotropic viral integration site 9 protein; Ecotropic viral integration site 9 protein homolog; Evi 9; EVI-9; Evi9; FLJ10173; FLJ34997; HBFQTL5; KIAA1809; Zinc finger protein 856; ZNF856. |
| 研究領(lǐng)域 | 腫瘤 轉(zhuǎn)錄調(diào)節(jié)因子 淋巴細(xì)胞 b-淋巴細(xì)胞 表觀遺傳學(xué) |
| 抗體來(lái)源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Mouse, (predicted: Human, Rat, Chicken, Rabbit, ) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000 ELISA=1:5000-10000 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 91kDa |
| 細(xì)胞定位 | 細(xì)胞核 細(xì)胞漿 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Ctip1:751-835/835 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲(chǔ) 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| PubMed | PubMed |
| 產(chǎn)品介紹 | This gene encodes a C2H2 type zinc-finger protein by its similarity to the mouse Bcl11a/Evi9 protein. The corresponding mouse gene is a common site of retroviral integration in myeloid leukemia, and may function as a leukemia disease gene, in part, through its interaction with BCL6. During hematopoietic cell differentiation, this gene is down-regulated. It is possibly involved in lymphoma pathogenesis since translocations associated with B-cell malignancies also deregulates its expression. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. Function: Functions as a myeloid and B-cell proto-oncogene. May play important roles in leukemogenesis and hematopoiesis. An essential factor in lymphopoiesis, is required for B-cell formation in fetal liver. May function as a modulator of the transcriptional repression activity of ARP1. Subunit: Interacts with TFCOUP1, PIAS3, ARP1 and EAR2 Subcellular Location: Cytoplasm. Nucleus. Associates with the nuclear body. Colocalizes with SUMO1 and SENP2 in nuclear speckles. Tissue Specificity: Expressed at high levels in brain, spleen thymus, bone marrow and testis. Expressed in CD34-positive myeloid precursor cells, B-cells, monocytes and megakaryocytes. Expression is tightly regulated during B-cell development. Post-translational modifications: Sumoylated by SUMO1. DISEASE: Note=Chromosomal aberrations involving BCL11A may be a cause of lymphoid malignancies. Translocation t(2;14)(p13;q32.3) causes BCL11A deregulation and amplification. Similarity: Contains 6 C2H2-type zinc fingers. SWISS: Q9H165 Gene ID: 53335 Database links: Entrez Gene: 53335 Human Entrez Gene: 14025 Mouse Omim: 606557 Human SwissProt: Q9H165 Human SwissProt: Q9QYE3 Mouse Unigene: 370549 Human Unigene: 441102 Mouse Unigene: 471050 Mouse Unigene: 53687 Mouse Unigene: 88824 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
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