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驅(qū)動(dòng)蛋白家族蛋白13B抗體
  • 產(chǎn)品貨號(hào)：
    BN40363R
  • 中文名稱：
    驅(qū)動(dòng)蛋白家族蛋白13B抗體
  • 英文名稱：
    Rabbit anti-KIF13B Polyclonal antibody
  • 品牌：
    Biorigin

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  • BN40363R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Mouse,Rat(predicted:Human,Pig,Cow,Horse,Sheep) 推薦應(yīng)用：WB,IHC-P,IHC-F,ICC,IF,ELISA

  • BN40363R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Mouse,Rat(predicted:Human,Pig,Cow,Horse,Sheep) 推薦應(yīng)用：WB,IHC-P,IHC-F,ICC,IF,ELISA

產(chǎn)品描述

英文名稱KIF13B
中文名稱驅(qū)動(dòng)蛋白家族蛋白13B抗體
別    名GAKIN; Guanylate kinase associated kinesin; KI13B_HUMAN; KIAA0639; KIF 13B; KIF13B; Kinesin 13B; Kinesin family member 13B; Kinesin like protein GAKIN; Kinesin like protein KIF13B; Kinesin-like protein GAKIN; Kinesin-like protein KIF13B; OTTHUMP00000225649.  
研究領(lǐng)域細(xì)胞生物  神經(jīng)生物學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  細(xì)胞骨架  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Mouse, Rat,  (predicted: Human, Pig, Cow, Horse, Sheep, )
產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:200-800 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量203kDa
細(xì)胞定位細(xì)胞漿 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human KIF13B:351-450/1826 
亞    型IgG
純化方法affinity purified by Protein A
儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹KIF13B is also known as Kinesin-like protein GAKIN or GAKIN and is a 1,826 amino acid protein that is widely expressed in tissues, with highest expression in brain and kidney. KIF13B is localized to the cytoplasm, as well as to the cytoskeleton, and is thought to be a microtubule-dependent motor protein which is able to bind to a variety of proteins in order to traffic them to various locations throughout the cell. KIF13B belongs to the kinesin-like protein family and possesses three domains typical of the kinesin-like protein family, namely an N-terminal motor domain with an ATP-binding motif, an FHA domain which is known to bind diverse cargos and a large stalk domain involved in protein-protein binding. Additionally, KIF13B has a microtubule-interacting sequence which is known as the CAP-Gly domain at its C-terminus. The CAP-Gly domain is highly conserved domain among eukaryotes, and in humans, defects in the CAP-Gly domain are implicated in many diseases affecting the trafficking of vesicles, neuromuscular junctions and lysosome proliferation.

Function:
May be involved in reorganization of the cortical cytoskeleton. May be functionally important for the intracellular trafficking of MAGUKs and associated protein complexes.

Subunit:
Binds to DLG1 and DLG4. Interacts (when phosphorylated at Ser-1381 and Ser-1410) with 14-3-3.

Subcellular Location:
Cytoplasm; cytoskeleton.

Tissue Specificity:
Ubiquitous.

Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR.

Similarity:
Belongs to the kinesin-like protein family.
Contains 1 CAP-Gly domain.
Contains 1 FHA domain.
Contains 1 kinesin-motor domain.

SWISS:
Q9NQT8

Gene ID:
23303

Database links:

Entrez Gene: 23303 Human

Entrez Gene: 16554 Mouse

Entrez Gene: 305967 Rat

Omim: 607350 Human

SwissProt: Q9NQT8 Human

Unigene: 444767 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

















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