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磷酸化肢體畸形相關(guān)蛋白FHOD1抗體
  • 產(chǎn)品貨號：
    BN40410R
  • 中文名稱：
    磷酸化肢體畸形相關(guān)蛋白FHOD1抗體
  • 英文名稱：
    Rabbit anti-phospho-FHOD1 (Thr1141) Polyclonal antibody
  • 品牌：
    Biorigin

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  • BN40410R-100ul

    100ul

    ￥2470.00

    交叉反應：Human,Rat(predicted:Mouse,Chicken,Dog,Pig,Cow,Horse,Rabbit) 推薦應用：WB,IHC-P,IHC-F,ICC,IF,ELISA

產(chǎn)品描述

英文名稱phospho-FHOD1 (Thr1141)
中文名稱磷酸化肢體畸形相關(guān)蛋白FHOD1抗體
別    名FHOD1 (phospho T1141); p-FHOD1 (phospho T1141); FH1/FH2 domain containing protein; FH1/FH2 domain-containing protein 1; Fhod1; FHOD1_HUMAN; FHOS; FHOS1; Formin homolog overexpressed in spleen 1; Formin homology 2 domain containing 1; Formin homology 2 domain containing protein 1; Formin homology 2 domain-containing protein 1.  
產(chǎn)品類型磷酸化抗體 
研究領(lǐng)域細胞生物  信號轉(zhuǎn)導  結(jié)合蛋白  細胞骨架  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應Human, Rat,  (predicted: Mouse, Chicken, Dog, Pig, Cow, Horse, Rabbit, )
產(chǎn)品應用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量126kDa
細胞定位細胞漿 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthesised phosphopeptide derived from human FHOD1 around the phosphorylation site of Thr1141:RR(p-T)LK 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹The limb deformity (ld) locus influences normal limb development and gives rise to alternative mRNAs that can translate into a family of protein products known as formins. Formins play a crucial role in cytoskeletal reorganization by influencing actin filament assembly. The temporal genetic hierarchy influencing normal limb development can deregulate and mediate mammalian developmental syndromes. FHOD1 induces the formation of and associates with bundled actin stress fibers in response to the activity of the Rho-ROCK cascade. It influences several cellular activities including cell migration, cytoskeletal arrangement, signal transduction and gene expression.

Function:
Required for the assembly of F-actin structures, such as stress fibers. Depends on the Rho-ROCK cascade for its activity. Contributes to the coordination of microtubules with actin fibers and plays a role in cell elongation.

Subcellular Location:
Cytoplasm. Cytoplasm > cytoskeleton. Predominantly cytoplasmic.

Tissue Specificity:
Ubiquitous. Highly expressed in spleen.

Similarity:
Belongs to the formin homology family.
Contains 1 FH1 (formin homology 1) domain.
Contains 1 FH2 (formin homology 2) domain.
Contains 1 GBD/FH3 (Rho GTPase-binding/formin homology 3) domain.

SWISS:
Q9Y613

Gene ID:
29109

Database links:

Entrez Gene: 29109 Human

Omim: 606881 Human

SwissProt: Q9Y613 Human

Unigene: 95231 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.