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RAB27A蛋白單克隆抗體
  • 產(chǎn)品貨號(hào)：
    BN42064M
  • 中文名稱：
    RAB27A蛋白單克隆抗體
  • 英文名稱：
    Mouse anti-RAB27A Monoclonal antibody
  • 品牌：
    Biorigin

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  • BN42064M-50ul

    50ul

    ￥2020.00

    交叉反應(yīng)：Human 推薦應(yīng)用：WB,Flow-Cyt

  • BN42064M-100ul

    100ul

    ￥3240.00

    交叉反應(yīng)：Human 推薦應(yīng)用：WB,Flow-Cyt

產(chǎn)品描述

英文名稱RAB27A
中文名稱RAB27A蛋白單克隆抗體
別    名GS2; GTP-binding protein Ram; HsT18676; MGC117246; Rab-27; RAB-27A; RAB27; RAB27A; RAB27A member RAS oncogene family; RAM; Ras-related protein Rab-27A; Ras-related protein Rab27A; RB27A_HUMAN.  
研究領(lǐng)域腫瘤  細(xì)胞生物  轉(zhuǎn)錄調(diào)節(jié)因子  合成與降解  轉(zhuǎn)運(yùn)蛋白  
抗體來源Mouse
克隆類型Monoclonal
克 隆 號(hào)9C6
交叉反應(yīng)Human, 
產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:500-2000 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量25kDa
細(xì)胞定位細(xì)胞漿 細(xì)胞膜 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human RAB27A: 
亞    型IgG1
純化方法affinity purified by Protein G
儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹The protein encoded by this gene belongs to the small GTPase superfamily, Rab family. The protein is membrane-bound and may be involved in protein transport and small GTPase mediated signal transduction. Mutations in this gene are associated with Griscelli syndrome type 2. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified. [provided by RefSeq].

Function:
Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse.

Subunit:
Binds SYTL1, SLAC2B, MYRIP, SYTL3, SYTL4 and SYTL5 (By similarity). Binds MLPH and SYTL2. Interacts with UNC13D.

Subcellular Location:
Membrane; Lipid-anchor. Melanosome. Late endosome. Lysosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Localizes to endosomal exocytic vesicles.

Tissue Specificity:
Found in all the examined tissues except in brain. Low expression was found in thymus, kidney, muscle and placenta. Detected in melanocytes, and in most tumor cell lines examined. Expressed in cytotoxic T-lymphocytes (CTL) and mast cells.

DISEASE:
Griscelli syndrome 2 (GS2) [MIM:607624]: Rare autosomal recessive disorder that results in pigmentary dilution of the skin and hair, the presence of large clumps of pigment in hair shafts, and an accumulation of melanosomes in melanocytes. GS2 patients also develop an uncontrolled T-lymphocyte and macrophage activation syndrome, known as hemophagocytic syndrome, leading to death in the absence of bone marrow transplantation. Neurological impairment is present in some patients, likely as a result of hemophagocytic syndrome. Note=The disease is caused by mutations affecting the gene represented in this entry.

Similarity:
Belongs to the small GTPase superfamily. Rab family.

SWISS:
P51159

Gene ID:
5873

Database links:

Entrez Gene: 5873 Human

Entrez Gene: 11891 Mouse

Entrez Gene: 50645 Rat

Omim: 603868 Human

SwissProt: P51159 Human

SwissProt: Q9ERI2 Mouse

SwissProt: P23640 Rat

Unigene: 654978 Human

Unigene: 480676 Mouse

Unigene: 37360 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.


















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