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α型-過(guò)氧化酶活化增生受體單克隆抗體
  • 產(chǎn)品貨號(hào)：
    BN42067M
  • 中文名稱：
    α型-過(guò)氧化酶活化增生受體單克隆抗體
  • 英文名稱：
    Mouse anti-PPAR alpha Monoclonal antibody
  • 品牌：
    Biorigin

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  • BN42067M-50ul

    50ul

    ￥2020.00

    交叉反應(yīng)：Human,Mouse 推薦應(yīng)用：WB,IHC-P,ICC,IF

  • BN42067M-100ul

    100ul

    ￥3240.00

    交叉反應(yīng)：Human,Mouse 推薦應(yīng)用：WB,IHC-P,ICC,IF

產(chǎn)品描述

英文名稱PPAR alpha
中文名稱α型-過(guò)氧化酶活化增生受體單克隆抗體
別    名hPPAR; MGC2237; MGC2452; NR1C1; Nuclear receptor subfamily 1 group C member 1; Peroxisome Proliferator Activated Receptor alpha; PPAR; PPARA; OTTHUMP00000197740; OTTHUMP00000197741; Peroxisome proliferator-activated receptor alpha; PPAR-alpha; PPARA_HUMAN; PPARalpha.  
研究領(lǐng)域腫瘤  免疫學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  轉(zhuǎn)錄調(diào)節(jié)因子  激酶和磷酸酶  
抗體來(lái)源Mouse
克隆類型Monoclonal
克 隆 號(hào)7G5
交叉反應(yīng)Human,  (predicted: Mouse, )
產(chǎn)品應(yīng)用WB=1:500-1000 IHC-P=1:20-100 ICC=1:20-100 IF=1:20-100 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量51kDa
細(xì)胞定位細(xì)胞漿 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human PPAR alpha: 
亞    型IgG1
純化方法affinity purified by Protein G
儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹Peroxisome proliferators are nongenotoxic carcinogens which are purported to exert their effect on cells through their interaction with members of the nuclear hormone receptor family, termed Peroxisome Proliferator Activated Receptors (PPARs). Nuclear hormone receptors are ligand dependent intracellular proteins that stimulate transcription of specific genes by binding to specific DNA sequences following activation by the appropriate ligand. Studies indicate that PPARs are activated by peroxisome proliferators such as clofibric acid, nafenopin, and WY-14,643, as well as by some fatty acids. It has also been shown that PPARs can induce transcription of acyl coenzyme A oxidase and cytochrome P450 A6 (CYP450 A6) through interaction with specific response elements. PPAR alpha is activated by free fatty acids including linoleic, arachidonic, and oleic acids. Induction of peroxisomes by this mechanism leads to a reduction in blood triglyceride levels. PPAR alpha is expressed mainly in skeletal muscle, heart, liver, and kidney and is thought to regulate many genes involved in the beta-oxidation of fatty acids. Activation of rat liver PPAR alpha has been shown to suppress hepatocyte apoptosis. PPAR alpha, like several other nuclear hormone receptors, heterodimerizes with retinoic X receptor (RXR) alpha to form a transcriptionally competent complex.

Function:
Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety (By similarity). Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2.

Subunit:
Heterodimer; with RXRA. This heterodimerization is required for DNA binding and transactivation activity. Interacts with AKAP13, LPIN1 and PRDM16. Also interacts with PPARBP coactivator in vitro. Interacts with CITED2; the interaction stimulates its transcriptional activity. Interacts with NCOA3 and NCOA6 coactivators. Interacts with ASXL1 AND ASXL2.

Subcellular Location:
Nucleus.

Tissue Specificity:
Skeletal muscle, liver, heart and kidney.

Similarity:
Belongs to the nuclear hormone receptor family. NR1 subfamily.
Contains 1 nuclear receptor DNA-binding domain.

SWISS:
Q07869

Gene ID:
5465

Database links:

Entrez Gene: 5465 Human

Entrez Gene: 19013 Mouse

Entrez Gene: 25747 Rat

Omim: 170998 Human

SwissProt: Q07869 Human

SwissProt: Q6I9S0 Human

SwissProt: P23204 Mouse

SwissProt: Q542P9 Mouse

SwissProt: P37230 Rat

Unigene: 103110 Human

Unigene: 710044 Human

Unigene: 212789 Mouse

Unigene: 9753 Rat



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