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ADAM17重組兔單克隆抗體
  • 產(chǎn)品貨號：
    BN42068R
  • 中文名稱：
    ADAM17重組兔單克隆抗體
  • 英文名稱：
    Rabbit anti-ADAM17 (9E7) Monoclonal antibody
  • 品牌：
    Biorigin

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  • BN42068R-50ul

    50ul

    ￥2020.00

    交叉反應(yīng)：Human,Mouse(predicted:Rat) 推薦應(yīng)用：WB,IHC-P,IHC-F,IF,ELISA

  • BN42068R-100ul

    100ul

    ￥3240.00

    交叉反應(yīng)：Human,Mouse(predicted:Rat) 推薦應(yīng)用：WB,IHC-P,IHC-F,IF,ELISA

產(chǎn)品描述

英文名稱ADAM17 (9E7)
中文名稱ADAM17重組兔單克隆抗體
別    名A disintegrin and metalloproteinase domain 17; ADAM 17; ADAM metallopeptidase domain 17; ADAM17 protein; CD 156b; CD156b; CD156b antigen; CSVP; MGC71942; Snake venom like protease; TACE; TNF alpha convertase; TNF alpha converting enzyme; Tumor Necrosis Factor Alpha Converting Enzyme; A disintegrin and metalloproteinase domain 17 (tumor necrosis factor, alpha, converting enzyme); ADA17_HUMAN.  
研究領(lǐng)域腫瘤  免疫學(xué)  神經(jīng)生物學(xué)  信號轉(zhuǎn)導(dǎo)  轉(zhuǎn)錄調(diào)節(jié)因子  
抗體來源Rabbit
克隆類型Monoclonal
克 隆 號9E7
交叉反應(yīng)Human, Mouse,  (predicted: Rat, )
產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:20-200 IHC-F=1:20-200 ICC=1:20-200 IF=1:20-200 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量93kDa
細胞定位細胞膜 
性    狀Liquid
濃    度1mg/ml
免 疫 原Recombinant human ADAM17 protein:700-824/824 <Cytoplasmic>
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene functions as a tumor necrosis factor-alpha converting enzyme; binds mitotic arrest deficient 2 protein; and also plays a prominent role in the activation of the Notch signaling pathway. [provided by RefSeq].

Subunit:
Interacts with MAD2L1, MAPK14 and MUC1.

Subcellular Location:
Membrane.

Tissue Specificity:
Ubiquitously expressed. Expressed at highest levels in adult heart, placenta, skeletal muscle, pancreas, spleen, thymus, prostate, testes, ovary and small intestine, and in fetal brain, lung, liver and kidney.

Similarity:
Contains 1 disintegrin domain.
Contains 1 peptidase M12B domain.

SWISS:
P78536

Gene ID:
6868

Database links:

Entrez Gene: 6868 Human

Entrez Gene: 11491 Mouse

Entrez Gene: 57027 Rat

Omim: 603639 Human

SwissProt: P78536 Human

SwissProt: Q9Z0F8 Mouse

SwissProt: Q9Z1K9 Rat

Unigene: 404914 Human

Unigene: 27681 Mouse

Unigene: 144585 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.