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細(xì)胞色素C重組兔單克隆抗體
  • 產(chǎn)品貨號(hào)：
    BN42074R
  • 中文名稱：
    細(xì)胞色素C重組兔單克隆抗體
  • 英文名稱：
    Rabbit anti-Cytochrome C Monoclonal antibody
  • 品牌：
    Biorigin

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  • BN42074R-50ul

    50ul

    ￥2020.00

    交叉反應(yīng)：Rat,Mouse,Human 推薦應(yīng)用：WB,IHC-P,IHC-F,ICC,IF

  • BN42074R-100ul

    100ul

    ￥3240.00

    交叉反應(yīng)：Rat,Mouse,Human 推薦應(yīng)用：WB,IHC-P,IHC-F,ICC,IF

產(chǎn)品描述

英文名稱Cytochrome C
中文名稱細(xì)胞色素C重組兔單克隆抗體
別    名CytC; CYC; CYCS; Cytochrome c somatic; HCS; CYC_HUMAN; Cytochrome-c; MSA06; THC4.   
研究領(lǐng)域腫瘤  心血管  細(xì)胞生物  神經(jīng)生物學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  細(xì)胞凋亡  脂蛋白  新陳代謝  線粒體  
抗體來(lái)源Rabbit
克隆類型Monoclonal
克 隆 號(hào)1F10
交叉反應(yīng)Human, Mouse, Rat, 
產(chǎn)品應(yīng)用WB=1:500-1000 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200 IF=1:50-200 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量12.8/26kDa
細(xì)胞定位細(xì)胞漿 細(xì)胞膜 線粒體
性    狀Liquid
濃    度1mg/ml
免 疫 原Recombinant human Cytochrome C protein, full length: 
亞    型IgG
純化方法affinity purified by Protein A
儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹Cytochrome C is an electron transporting protein that resides within the intermembrane space of the mitochondria, where it plays a critical role in the process of oxidative phosphorylation and production of cellular ATP. An increasing amount of interest has been directed toward the role which cytocrome C has been demonstrated to play in apoptotic processes. Following exposure to apoptotic stimuli, cytochrome C is rapidly released from the mitochondria into the cytosol, an event which may be required for the completion of apoptosis in some systems. Cytosolic cytochrome C functions in the activation of caspase 3, an ICE family molecule that is a key effector of apoptosis.

Function:
Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases.

Subcellular Location:
Mitochondrion intermembrane space. Note=Loosely associated with the inner membrane.

Post-translational modifications:
Binds 1 heme group per subunit.
Phosphorylation at Tyr-49 and Tyr-98 both reduce by half the turnover in the reaction with cytochrome c oxidase, down-regulating mitochondrial respiration.

DISEASE:
Defects in CYCS are the cause of thrombocytopenia type 4 (THC4) [MIM:612004]; also known as autosomal dominant thrombocytopenia type 4. Thrombocytopenia is the presence of relatively few platelets in blood. THC4 is a non-syndromic form of thrombocytopenia. Clinical manifestations of thrombocytopenia are absent or mild. THC4 may be caused by dysregulated platelet formation.

Similarity:
Belongs to the cytochrome c family.

SWISS:
P99999

Gene ID:
54205

Database links:

Entrez Gene: 54205 Human

Entrez Gene: 13063 Mouse

Entrez Gene: 25309 Rat

Omim: 123970 Human

SwissProt: P99999 Human

SwissProt: P62897 Mouse

SwissProt: P62898 Rat

Unigene: 437060 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.