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細(xì)胞角蛋白2e重組兔單克隆抗體
  • 產(chǎn)品貨號(hào)：
    BN42077R
  • 中文名稱：
    細(xì)胞角蛋白2e重組兔單克隆抗體
  • 英文名稱：
    Rabbit anti-Cytokeratin 2e Monoclonal antibody
  • 品牌：
    Biorigin

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  • BN42077R-50ul

    50ul

    ￥2020.00

    交叉反應(yīng)：Human 推薦應(yīng)用：WB,IHC-P,IHC-F,ICC,IF,ELISA

  • BN42077R-100ul

    100ul

    ￥3240.00

    交叉反應(yīng)：Human 推薦應(yīng)用：WB,IHC-P,IHC-F,ICC,IF,ELISA

產(chǎn)品描述

英文名稱Cytokeratin 2e
中文名稱細(xì)胞角蛋白2e重組兔單克隆抗體
別    名K 2e; Cytokeratin-2e; Epithelial keratin-2e; K2e; Keratin type II cytoskeletal 2 epidermal; Keratin-2 epidermis; KRT2; K22E_HUMAN; KRT2A; KRT2E; Type-II keratin Kb2.  
研究領(lǐng)域信號(hào)轉(zhuǎn)導(dǎo)  
抗體來(lái)源Rabbit
克隆類型Monoclonal
克 隆 號(hào)2F7
交叉反應(yīng)Human, 
產(chǎn)品應(yīng)用WB=1:500-1000 ELISA=1:5000-10000 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200 IF=1:50-200 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量70kDa
細(xì)胞定位細(xì)胞漿 
性    狀Liquid
濃    度1mg/ml
免 疫 原Recombinant human Cytokeratin 2e protein, around 350-500aa: 
亞    型IgG
純化方法affinity purified by Protein A
儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is expressed largely in the upper spinous layer of epidermal keratinocytes and mutations in this gene have been associated with bullous congenital ichthyosiform erythroderma. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008]

Function:
Keratins are the major gene product of keratinocytes and form the intermediate filament cytoskeletal network in these cells. In cells of the upper spinous layer, KRT2E and KRT9 are expressed. Although the expression of KRT9 is limited to palmoplantar epidermis, KRT2E is expressed not only in this tissue but also in other regions, notably the epidermis covering the knee, thigh, and groin. It is not known whether these keratins simply replace their respective type I or type II counterpart in the preexisting KRT1/KRT10 network or dimerize with another, as yet undiscovered keratin partner.

Subunit:
Heterotetramer of two type I and two type II keratins. Associates with KRT10.

Subcellular Location:
Cytoplasmic.

Tissue Specificity:
Expressed in the upper spinous and granular suprabasal layers of normal adult epidermal tissues from most body sites including thigh, breast nipple, foot sole, penile shaft and axilla. Not present in foreskin, squamous metaplasias and carcinomas. Expression in hypertrophic and keloid scars begins in the deepest suprabasal layer. Weakly expressed in normal gingival and tongue, however expression is induced in benign keratoses of lingual mucosa and in mild-to-moderate oral dysplasia with orthokeratinization.

DISEASE:
Ichthyosis bullosa of Siemens (IBS) [MIM:146800]: A rare autosomal dominant skin disorder displaying a type of epidermolytic hyperkeratosis characterized by generalized erythema and extensive blistering from birth. Large, dark gray hyperkeratoses are observed in later weeks. The skin of IBS patients is unusually fragile and has a tendency to shed the outer layers of the epidermis, producing localized denuded areas (molting effect). IBS usually improves with age so that in most middle-aged patients the hyperkeratosis and keratotic lichenification is limited to the flexural folds of the major joints. Note=The disease is caused by mutations affecting the gene represented in this entry.

Similarity:
Belongs to the intermediate filament family.

SWISS:
P35908

Gene ID:
3849

Database links:

Entrez Gene: 3849 Human

Omim: 600194 Human

SwissProt: P35908 Human

Unigene: 707 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic application