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細胞角蛋白5重組兔單克隆抗體
  • 產(chǎn)品貨號：
    BN42078R
  • 中文名稱：
    細胞角蛋白5重組兔單克隆抗體
  • 英文名稱：
    Rabbit anti-Cytokeratin 5 Monoclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產(chǎn)品規(guī)格

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  • BN42078R-50ul

    50ul

    ￥2020.00

    交叉反應：Human,Mouse(predicted:Rat) 推薦應用：WB,IHC-P,IHC-F,ICC,IF

  • BN42078R-100ul

    100ul

    ￥3240.00

    交叉反應：Human,Mouse(predicted:Rat) 推薦應用：WB,IHC-P,IHC-F,ICC,IF

產(chǎn)品描述

英文名稱Cytokeratin 5
中文名稱細胞角蛋白5重組兔單克隆抗體
別    名Active () Monoclonal Antibody Primary Antibody Unconjugated Rabbit Cytokeratin 5 Unmodified "WB(1:1000-2000) ICC(1:50-200), IHC(1:50-200), "   
研究領域腫瘤  信號轉導  
抗體來源Rabbit
克隆類型Monoclonal
克 隆 號2H5
交叉反應Human, Mouse,  (predicted: Rat, )
產(chǎn)品應用WB=1:500-2000 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200 IF=1:50-200 （石蠟切片需做抗原修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量64kDa
細胞定位細胞核 細胞漿 細胞外基質(zhì) 
性    狀Liquid
濃    度1mg/ml
免 疫 原Recombinant human Cytokeratin 5 protein (400-500aa): 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹Cytokeratins (CK) are intermediate filaments of epithelial cells, both in keratinising tissue (ie., skin) and non keratinising cells (ie., mesothelial cells). Although not a traditional marker for endothelial cells, cytokeratins have also been found in some microvascular endothelial cells. At least 20 different cytokeratins (CK) in the molecular range of 40 to 70 kDa and isoelectric points of 5 to 8.5 can be identified using two dimensional gel electrophoresis. Biochemically, most members of the CK family fall into one of two classes, type I (acidic polypeptides) and type II (basic polypeptides). At least one member of the acidic family and one member of the basic family is expressed in all epithelial cells. Defects in KRT5 are a cause of epidermolysis bullosa simplex.

Subunit:
Heterotetramer of two type I and two type II keratins. Keratin-5 associates with keratin-14. Interacts with TCHP.

DISEASE:
Defects in KRT5 are a cause of epidermolysis bullosa simplex Dowling-Meara type (DM-EBS) [MIM:131760]. DM-EBS is a severe form of intraepidermal epidermolysis bullosa characterized by generalized herpetiform blistering, milia formation, dystrophic nails, and mucous membrane involvement.
Defects in KRT5 are the cause of epidermolysis bullosa simplex with migratory circinate erythema (EBSMCE) [MIM:609352]. EBSMCE is a form of intraepidermal epidermolysis bullosa characterized by unusual migratory circinate erythema. Skin lesions appear from birth primarily on the hands, feet, and legs but spare nails, ocular epithelia and mucosae. Lesions heal with brown pigmentation but no scarring. Electron microscopy findings are distinct from those seen in the DM-EBS, with no evidence of tonofilament clumping.
Defects in KRT5 are a cause of epidermolysis bullosa simplex Weber-Cockayne type (WC-EBS) [MIM:131800]. WC-EBS is a form of intraepidermal epidermolysis bullosa characterized by blistering limited to palmar and plantar areas of the skin.
Defects in KRT5 are a cause of epidermolysis bullosa simplex Koebner type (K-EBS) [MIM:131900]. K-EBS is a form of intraepidermal epidermolysis bullosa characterized by generalized skin blistering. The phenotype is not fundamentally distinct from the Dowling-Meara type, althought it is less severe.
Defects in KRT5 are the cause of epidermolysis bullosa simplex with mottled pigmentation (MP-EBS) [MIM:131960]. MP-EBS is a form of intraepidermal epidermolysis bullosa characterized by blistering at acral sites and 'mottled' pigmentation of the trunk and proximal extremities with hyper- and hypopigmentation macules.
Defects in KRT5 are the cause of Dowling-Degos disease (DDD) [MIM:179850]; also known as Dowling-Degos-Kitamura disease or reticulate acropigmentation of Kitamura. DDD is an autosomal dominant genodermatosis. Affected individuals develop a postpubertal reticulate hyperpigmentation that is progressive and disfiguring, and small hyperkeratotic dark brown papules that affect mainly the flexures and great skin folds. Patients usually show no abnormalities of the hair or nails.

Similarity:
Belongs to the intermediate filament family.

SWISS:
P13647

Gene ID:
3852

Database links:

Entrez Gene: 3852 Human

Entrez Gene: 110308 Mouse

Entrez Gene: 369017 Rat

Omim: 148040 Human

SwissProt: P13647 Human

SwissProt: Q922U2 Mouse

SwissProt: Q6P6Q2 Rat

Unigene: 433845 Human

Unigene: 451847 Mouse

Unigene: 129725 Rat

Unigene: 195318 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications