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叉頭蛋白P3重組兔單克隆抗體
  • 產(chǎn)品貨號：
    BN42081R
  • 中文名稱：
    叉頭蛋白P3重組兔單克隆抗體
  • 英文名稱：
    Rabbit anti-FOXP3 Monoclonal antibody
  • 品牌：
    Biorigin

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  • BN42081R-50ul

    50ul

    ￥2020.00

    交叉反應(yīng)：Human 推薦應(yīng)用：WB,IHC-P,IHC-F,IF,Flow-Cyt

  • BN42081R-100ul

    100ul

    ￥3240.00

    交叉反應(yīng)：Human 推薦應(yīng)用：WB,IHC-P,IHC-F,IF,Flow-Cyt

產(chǎn)品描述

英文名稱FOXP3
中文名稱叉頭蛋白P3重組兔單克隆抗體
別    名AIID; AIID; DIETER; DIETER; Forkhead box P3; Forkhead box protein P3; FOXP3_HUMAN; FOXP3delta7; Immune dysregulation polyendocrinopathy enteropathy X linked; Immunodeficiency polyendocrinopathy enteropathy X linked; IPEX; IPEX; JM2; JM2; MGC141961; MGC141963; OTTHUMP00000025832; OTTHUMP00000025833; OTTHUMP00000226737; PIDX; PIDX; SCURFIN; SCURFIN; XPID; XPID.  
研究領(lǐng)域轉(zhuǎn)錄調(diào)節(jié)因子  
抗體來源Rabbit
克隆類型Monoclonal
克 隆 號12B1
交叉反應(yīng)Human, 
產(chǎn)品應(yīng)用WB=1:500-2000 IP=1:20-100 IHC-P=1:50-200 IHC-F=1:50-200 Flow-Cyt=2ug/Test ICC=1:50-200 IF=1:50-200 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量47kDa
細胞定位細胞核 
性    狀Liquid
濃    度1mg/ml
免 疫 原Recombinant human FOXP3 protein, around C-terminal 150aa: 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹The protein encoded by this gene is a member of the forkhead/winged-helix family of transcriptional regulators. Defects in this gene are the cause of immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX), also known as X-linked autoimmunity-immunodeficiency syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008].

Function:
Probable transcription factor. Plays a critical role in the control of immune response.

Subunit:
Interacts with IKZF3.

Subcellular Location:
Nucleus (Potential).

Post-translational modifications:
Acetylation on lysine residues stabilizes FOXP3 and promotes differentiation of T-cells into induced regulatory T-cells (iTregs) associated with suppressive functions. Deacetylated by SIRT1.

DISEASE:
Defects in FOXP3 are the cause of immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) [MIM:304790]; also known as X-linked autoimmunity-immunodeficiency syndrome. IPEX is characterized by neonatal onset insulin-dependent diabetes mellitus, infections, secretory diarrhea, trombocytopenia, anemia and eczema. It is usually lethal in infancy.

Similarity:
Contains 1 C2H2-type zinc finger.
Contains 1 fork-head DNA-binding domain.

SWISS:
Q9BZS1

Gene ID:
50943

Database links:

Entrez Gene: 50943 Human

Entrez Gene: 20371 Mouse

Entrez Gene: 317382 Rat

Omim: 300292 Human

SwissProt: Q9BZS1 Human

SwissProt: Q99JB6 Mouse

SwissProt: D3ZKI1 Rat

Unigene: 247700 Human

Unigene: 182291 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.