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過氧化還原酶1重組兔單克隆抗體
  • 產(chǎn)品貨號(hào)：
    BN42088R
  • 中文名稱：
    過氧化還原酶1重組兔單克隆抗體
  • 英文名稱：
    Rabbit anti-Peroxiredoxin 1 Monoclonal antibody
  • 品牌：
    Biorigin

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  • BN42088R-50ul

    50ul

    ￥2020.00

    交叉反應(yīng)：Human,Mouse 推薦應(yīng)用：WB,IHC-P,IHC-F,IF

  • BN42088R-100ul

    100ul

    ￥3240.00

    交叉反應(yīng)：Human,Mouse 推薦應(yīng)用：WB,IHC-P,IHC-F,IF

產(chǎn)品描述

英文名稱Peroxiredoxin 1
中文名稱過氧化還原酶1重組兔單克隆抗體
別    名Peroxiredoxin-1; Peroxiredoxin 1; Prdx 1; Prdx1; PRDX1_HUMAN; Hbp23; Heme binding 23 kDa protein; Macrophage 23 Kd stress protein; Macrophage 23kDa stress protein; Macrophase stress protein 22kDa; Macrophase stress protein 23 kd; MSP23; Natural killer cell enhancing factor A; Natural killer cell-enhancing factor A; Natural killer enhancing factor A; NKEF A; NKEF-A; NkefA; OSF3; Osteoblast specific factor 3; PAG; Paga; PAGB; Proliferation associated gene A; Proliferation associated protein PAG; Proliferation-associated gene protein; PrxI; Tdpx 2; Tdpx2; TDX2; Thioredoxin dependent peroxide reductase 2; Thioredoxin peroxidase 2; Thioredoxin-dependent peroxide reductase 2; TPxA; Trx dependent peroxide reductase 2.  
研究領(lǐng)域腫瘤  細(xì)胞生物  免疫學(xué)  
抗體來源Rabbit
克隆類型Monoclonal
克 隆 號(hào)7A1
交叉反應(yīng)Human, Mouse, 
產(chǎn)品應(yīng)用WB=1:500-2000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:50-200 IF=1:50-200 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量22kDa
細(xì)胞定位細(xì)胞漿 細(xì)胞膜 
性    狀Liquid
濃    度1mg/ml
免 疫 原Recombinant human Peroxiredoxin 1 protein, full length: 
亞    型IgG
純化方法affinity purified by Protein A
儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein may play an antioxidant protective role in cells, and may contribute to the antiviral activity of CD8(+) T-cells. This protein may have a proliferative effect and play a role in cancer development or progression. Four transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jan 2011].

Function:
Involved in redox regulation of the cell. Reduces peroxides with reducing equivalents provided through the thioredoxin system but not from glutaredoxin. May play an important role in eliminating peroxides generated during metabolism. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2). Reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron differentiation.

Subunit:
Homodimer; disulfide-linked, upon oxidation. May form heterodimers with AOP2. Interacts with GDPD5; forms a mixed-disulfide with GDPD5 (By similarity).

Subcellular Location:
Cytoplasm. Melanosome.

Post-translational modifications:
Phosphorylated on Thr-90 during the M-phase, which leads to a more than 80% decrease in enzymatic activity.

Similarity:
Belongs to the AhpC/TSA family.
Contains 1 thioredoxin domain.

SWISS:
Q06830

Gene ID:
5052

Database links:

Entrez Gene: 281997 Cow

Entrez Gene: 5052 Human

Entrez Gene: 18477 Mouse

Entrez Gene: 117254 Rat

Omim: 176763 Human

SwissProt: Q9JKY1 Chinese Hamster

SwissProt: Q06830 Human

SwissProt: P35700 Mouse

SwissProt: Q63716 Rat

Unigene: 180909 Human

Unigene: 30929 Mouse

Unigene: 2845 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.