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Caspase-6重組兔單克隆抗體
  • 產(chǎn)品貨號(hào)：
    BN42138R
  • 中文名稱：
    Caspase-6重組兔單克隆抗體
  • 英文名稱：
    Rabbit anti-Caspase-6 Monoclonal antibody
  • 品牌：
    Biorigin

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  • BN42138R-50ul

    50ul

    ￥2020.00

    交叉反應(yīng)：Human,Mouse,Rat 推薦應(yīng)用：WB,IHC-P,IHC-F,ICC,IF

  • BN42138R-100ul

    100ul

    ￥3240.00

    交叉反應(yīng)：Human,Mouse,Rat 推薦應(yīng)用：WB,IHC-P,IHC-F,ICC,IF

產(chǎn)品描述

英文名稱Caspase-6
中文名稱Caspase-6重組兔單克隆抗體
別    名Apoptosis-related cysteine protein; Apoptosis Related Cysteine Protease; Apoptotic cysteine protease MCH2; Apoptotic protease MCH 2; Apoptotic protease MCH2; Casp 6; Casp6; Caspase 6 apoptosis related cysteine protease; Caspase 6 precursor; Caspase6; Human cysteine protease Mch2 isoform alpha; Mch 2; Mch2; CASP6_HUMAN.  
研究領(lǐng)域細(xì)胞生物  細(xì)胞凋亡  
抗體來(lái)源Rabbit
克隆類型Monoclonal
克 隆 號(hào)10F5
交叉反應(yīng)Human, Mouse, Rat, 
產(chǎn)品應(yīng)用WB=1:1000-2000 IP=1:10-50 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200 IF=1:50-200 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量33kDa
細(xì)胞定位細(xì)胞核 細(xì)胞漿 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human Caspase-6: 
亞    型IgG
純化方法affinity purified by Protein A
儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein is processed by caspases 7, 8 and 10, and is thought to function as a downstream enzyme in the caspase activation cascade. Alternative splicing of this gene results in two transcript variants that encode different isoforms. [provided by RefSeq, Jul 2008]

Function:
Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death.

Subunit:
Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 18 kDa (p18) and a 11 kDa (p11) subunit. Interacts with BIRC6/bruce.

Subcellular Location:
Cytoplasm.

Post-translational modifications:
Cleavages by caspase-3, caspase-8 or -10 generate the two active subunits.

Similarity:
Belongs to the peptidase C14A family.

SWISS:
P55212

Gene ID:
839

Database links:

Entrez Gene: 839 Human

Entrez Gene: 12368 Mouse

Entrez Gene: 83584 Rat

Omim: 601532 Human

SwissProt: P55212 Human

SwissProt: O08738 Mouse

SwissProt: O35397 Rat

Unigene: 654616 Human

Unigene: 281379 Mouse

Unigene: 88160 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.














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