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膜粘連蛋白 Ⅱ重組兔單克隆抗體
  • 產(chǎn)品貨號：
    BN42151R
  • 中文名稱：
    膜粘連蛋白 Ⅱ重組兔單克隆抗體
  • 英文名稱：
    Rabbit anti-Annexin A2 (2F4) Monoclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產(chǎn)品規(guī)格

    售價

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  • BN42151R-50ul

    50ul

    ￥2020.00

    交叉反應(yīng)：Human 推薦應(yīng)用：WB,IHC-P,IHC-F,ICC,IF

  • BN42151R-100ul

    100ul

    ￥3240.00

    交叉反應(yīng)：Human 推薦應(yīng)用：WB,IHC-P,IHC-F,ICC,IF

產(chǎn)品描述

英文名稱Annexin A2 (2F4)
中文名稱膜粘連蛋白 Ⅱ重組兔單克隆抗體
別    名ANX 2; ANX2; ANX2L4; ANXA2; arylsulfatase B; CAL1H; Calpactin I heavy chain; calpactin I heavy polypeptide (p36); chromobindin 8; LIP2; Lipocortin II; LPC2; LPC2D; P36; P36 protein; PAP-IV; placental anticoagulant protein IV; Protein I; ANXA2_HUMAN; Annexin II; Annexin-2; Calpactin-1 heavy chain; Chromobindin-8; Placental anticoagulant protein IV.  
研究領(lǐng)域腫瘤  心血管  細胞生物  信號轉(zhuǎn)導(dǎo)  細胞凋亡  
抗體來源Rabbit
克隆類型Monoclonal
克 隆 號2F4
交叉反應(yīng)Human, 
產(chǎn)品應(yīng)用WB=1:300-1000 IHC-P=1:200-400 IHC-F=1:200-400 ICC=1:50-200 IF=1:50-200 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量36kDa
細胞定位細胞漿 細胞膜 細胞外基質(zhì) 分泌型蛋白 
性    狀Liquid
濃    度1mg/ml
免 疫 原Recombinant Human Annexin A2 : 1-200/339 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMedPubMed
產(chǎn)品介紹This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions as an autocrine factor which heightens osteoclast formation and bone resorption. This gene has three pseudogenes located on chromosomes 4, 9 and 10, respectively. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

Function:
Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response.

Subunit:
Heterotetramer containing 2 light chains of S100A10/p11 and 2 heavy chains of ANXA2/p36. Interacts with ATP1B1 and DYSF. Interacts with human cytomegalovirus (HCMV). Interacts with COCH.

Subcellular Location:
Secreted, extracellular space, extracellular matrix, basement membrane. Melanosome. Note=In the lamina beneath the plasma membrane. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Translocated from the cytoplasm to the cell surface through a Golgi-independent mechanism.

Post-translational modifications:
Phosphorylation of Tyr-24 enhances heat stress-induced translocation to the cell surface.
ISGylated.

Similarity:
Belongs to the annexin family.
Contains 4 annexin repeats.

SWISS:
P07355

Gene ID:
302

Database links:

Entrez Gene: 302 Human

Entrez Gene: 12306 Mouse

Entrez Gene: 56611 Rat

Omim: 151740 Human

SwissProt: P07355 Human

SwissProt: P07356 Mouse

SwissProt: Q07936 Rat

Unigene: 511605 Human

Unigene: 238343 Mouse

Unigene: 90546 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

信號傳導(dǎo)（Signaling Intermediates）
Annexin 2是新近發(fā)現(xiàn)的纖維蛋白溶解酶原(PLG)和組織型纖溶蛋白溶解酶原激活物(t-PA)的共受體,是Ca2+介導(dǎo)具有高親和力的磷脂結(jié)合蛋白.其介導(dǎo)血管內(nèi)外纖維蛋白溶解,對保持機體內(nèi)環(huán)境穩(wěn)定具有重要作用.
依賴性膜磷脂結(jié)合蛋白Annexin II調(diào)控異常及有害因子的作用,可導(dǎo)致血栓性疾病和動脈硬化癥
鈣依賴性膜磷脂結(jié)合蛋白膜粘連蛋白2異常高表達所引起纖溶亢進,是白血病等惡性腫瘤出血合并癥重要機制之一.鈣依賴性磷脂結(jié)合蛋白對其干預(yù)和調(diào)控可能為治療上述病癥提供新思路,為臨床治療開辟新途徑.