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細(xì)胞色素P450 17A1重組兔單克隆抗體
  • 產(chǎn)品貨號(hào)：
    BN42160R
  • 中文名稱：
    細(xì)胞色素P450 17A1重組兔單克隆抗體
  • 英文名稱：
    Rabbit anti-Cytochrome P450 17A1 Monoclonal antibody
  • 品牌：
    Biorigin

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  • BN42160R-50ul

    50ul

    ￥2020.00

    交叉反應(yīng)：Human,Mouse,Rat 推薦應(yīng)用：WB,IHC-P,IHC-F,ICC,IF

  • BN42160R-100ul

    100ul

    ￥3240.00

    交叉反應(yīng)：Human,Mouse,Rat 推薦應(yīng)用：WB,IHC-P,IHC-F,ICC,IF

產(chǎn)品描述

英文名稱Cytochrome P450 17A1
中文名稱細(xì)胞色素P450 17A1重組兔單克隆抗體
別    名CPT7; CYP17; CYP17A1; Cytochrome P450 17A1; CYPXVII; Cytochrome P450 family 17; Cytochrome P450 family 17 subfamily A polypeptide 1; Cytochrome p450 XVIIA1; Cytochrome p450, subfamily XVII (steroid 17 alpha hydroxylase) adrenal hyperplasia ; P450 C17; P450c17; S17AH; Steroid 17 alpha hydroxylase/17,20 lyase; Steroid 17 alpha monooxygenase; CP17A_HUMAN.  
研究領(lǐng)域腫瘤  細(xì)胞生物  免疫學(xué)  
抗體來(lái)源Rabbit
克隆類型Monoclonal
克 隆 號(hào)2F7
交叉反應(yīng)Human, Mouse, Rat, 
產(chǎn)品應(yīng)用WB=1:500 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200 IF=1:50-200 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量57kDa
細(xì)胞定位細(xì)胞膜 
性    狀Lyophilized or Liquid
濃    度1mg/ml
免 疫 原Recombinant human Cytochrome P450 17A1: 
亞    型IgG
純化方法affinity purified by Protein A
儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹Cytochrome P450 17A1 (CYP17A1) belongs to the cytochrome P450 family; it plays a role in the conversion of pregnenolone and progesterone into their 17-alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. CYP17A1 also catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction. CYP17A1 is involved in sexual development during fetal life and at puberty. Defects in CYP17A1 are the cause of adrenal hyperplasia type 5 (AH5). AH5 is a form of congenital adrenal hyperplasia, a common recessive disease due to defective synthesis of cortisol.

Function:
Conversion of pregnenolone and progesterone to their 17-alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction. Involved in sexual development during fetal life and at puberty.

Subcellular Location:
Membrane.

Post-translational modifications:
Phosphorylation is necessary for 17,20-lyase, but not for 17-alpha-hydroxylase activity.

DISEASE:
Defects in CYP17A1 are the cause of adrenal hyperplasia type 5 (AH5) [MIM:202110]. AH5 is a form of congenital adrenal hyperplasia, a common recessive disease due to defective synthesis of cortisol. Congenital adrenal hyperplasia is characterized by androgen excess leading to ambiguous genitalia in affected females, rapid somatic growth during childhood in both sexes with premature closure of the epiphyses and short adult stature. Four clinical types: "salt wasting" (SW, the most severe type), "simple virilizing" (SV, less severely affected patients), with normal aldosterone biosynthesis, "non-classic form" or late onset (NC or LOAH), and "cryptic" (asymptomatic).

Similarity:
Belongs to the cytochrome P450 family.

SWISS:
P05093

Gene ID:
1586

Database links:

Entrez Gene: 493967 Cat

Entrez Gene: 477807 Dog

Entrez Gene: 101831170 Hamster

Entrez Gene: 1586 Human

Omim: 609300 Human

SwissProt: Q9GMC8 Cat

SwissProt: Q8HYN1 Chimpanzee

SwissProt: P70687 Hamster

SwissProt: Q95328 Horse

SwissProt: P05093 Human

Unigene: 438016 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.