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CD34抗體
  • 產(chǎn)品貨號(hào)：
    BN42168R
  • 中文名稱：
    CD34抗體
  • 英文名稱：
    Rabbit anti-CD34 Monoclonal antibody
  • 品牌：
    Biorigin

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  • BN42168R-50ul

    50ul

    ￥2020.00

    交叉反應(yīng)：Rat,Mouse,Human(predicted:Dog) 推薦應(yīng)用：WB,IHC-P,IHC-F,ICC,IF,ELISA

  • BN42168R-100ul

    100ul

    ￥3240.00

    交叉反應(yīng)：Rat,Mouse,Human(predicted:Dog) 推薦應(yīng)用：WB,IHC-P,IHC-F,ICC,IF,ELISA

產(chǎn)品描述

英文名稱CD34
中文名稱CD34抗體
別    名CD34 antigen; CD34 molecule; Cluster designation 34; Hematopoietic progenitor cell antigen CD34; HPCA1; CD34_HUMAN.  
研究領(lǐng)域腫瘤  心血管  免疫學(xué)  發(fā)育生物學(xué)  神經(jīng)生物學(xué)  干細(xì)胞  細(xì)胞表面分子  糖蛋白  細(xì)胞類型標(biāo)志物  血管內(nèi)皮細(xì)胞  內(nèi)皮細(xì)胞  
抗體來(lái)源Rabbit
克隆類型Monoclonal
克 隆 號(hào)7A1
交叉反應(yīng)Mouse,  (predicted: Human, Rat, Dog, )
產(chǎn)品應(yīng)用ELISA=1:5000-10000 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200 IF=1:50-200 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量39kDa
細(xì)胞定位細(xì)胞膜 
性    狀Liquid
濃    度1mg/ml
免 疫 原Recombinant human CD34: 
亞    型IgG
純化方法affinity purified by Protein A
儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMedPubMed
產(chǎn)品介紹The highly glycosylated 75-120 kD antigen CD34 is possibly an adhesion molecule with a putative role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. It could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. CD34 is thought to have a role in presenting carbohydrate ligands to selectins. The intracellular chain of the CD34 antigen is a site of phosphorylation by activated protein kinase C, suggesting a putative role in signal transduction. Two isoforms of CD34 have been reported to be generated by alternative splicing. CD34 is highly expressed on hematopoietic progenitors, as well as on endothelial cells, brain, and testis. Staining for CD34 has been used to measure angiogenesis, which reportedly predicts tumor recurrence.

Function:
Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins.

Subcellular Location:
Membrane; Single-pass type I membrane protein.

Tissue Specificity:
Selectively expressed on hematopoietic progenitor cells and the small vessel endothelium of a variety of tissues.

Post-translational modifications:
Highly glycosylated.
Phosphorylated on serine residues by PKC.

Similarity:
Belongs to the CD34 family.

SWISS:
P28906

Gene ID:
947

Database links:

Entrez Gene: 947 Human

Omim: 142230 Human

SwissProt: P28906 Human

Unigene: 374990 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

造血干細(xì)胞標(biāo)志物
內(nèi)皮標(biāo)志物
腫瘤生物標(biāo)志物
細(xì)胞表面的唾液粘蛋白。
間充質(zhì)干細(xì)胞（mesenchymal stem cells,MSC）也是干細(xì)胞家族的重要成員，來(lái)源于發(fā)育早期的中胚層和外胚層。MSC最初在骨髓中發(fā)現(xiàn)，因其具有多向分化潛能、造血支持和促進(jìn)干細(xì)胞植入、免疫調(diào)控和自我復(fù)制等特點(diǎn)。如間充質(zhì)干細(xì)胞在體內(nèi)或體外特定的誘導(dǎo)條件下，可分化為血管內(nèi)皮、脂肪、骨、軟骨、肌肉、肌腱、韌帶、神經(jīng)、肝、心肌、等多種組織細(xì)胞。