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白介素1β/IL-1β抗體
  • 產(chǎn)品貨號(hào)：
    BN42184R
  • 中文名稱：
    白介素1β/IL-1β抗體
  • 英文名稱：
    Rabbit anti-IL-1 Beta Polyclonal antibody
  • 品牌：
    Biorigin

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  • BN42184R-50ul

    50ul

    ￥1486.00

    交叉反應(yīng)：Rat,Mouse,Human 推薦應(yīng)用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA

  • BN42184R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Rat,Mouse,Human 推薦應(yīng)用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA

  • BN42184R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Rat,Mouse,Human 推薦應(yīng)用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA

產(chǎn)品描述

英文名稱IL-1 Beta
中文名稱白介素1β/IL-1β抗體
別    名Catabolin; H1; IL-1β; Hematopoietin 1; IFN beta inducing factor; IL 1; IL 1 beta; IL 1B; IL1B; IL1F2; Interleukin 1 beta; Interleukin 1 beta precursor; LAF; OAF; Osteoclast activating factor; Preinterleukin beta; Pro interleukin 1 beta; IL1B_HUMAN; Interleukin-1 beta; IL-1 beta.  


研究領(lǐng)域細(xì)胞生物  免疫學(xué)  糖蛋白  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Human, Mouse, Rat,  (predicted: Dog, Pig, Rabbit, Guinea Pig, )
產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1μg/Test IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量17/32kDa
細(xì)胞定位分泌型蛋白 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human IL-1beta:101-200/269 
亞    型IgG
純化方法affinity purified by Protein A
儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. [provided by RefSeq, Jul 2008].

Function:
Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.

Subunit:
Monomer.

Subcellular Location:
Secreted. Note=The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins.

Similarity:
Belongs to the IL-1 family.

SWISS:
P01584

Gene ID:
3553

Database links:

Entrez Gene: 3553 Human

Entrez Gene: 16176 Mouse

Entrez Gene: 24494 Rat

Omim: 147720 Human

SwissProt: P01584 Human

SwissProt: P10749 Mouse

SwissProt: Q63264 Rat

Unigene: 126256 Human

Unigene: 222830 Mouse

Unigene: 9869 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

生長(zhǎng)因子和激素（ Growth Factor and Hormones）
IL-1β是一種糖蛋白，它既可誘導(dǎo)急性期時(shí)相關(guān)蛋白的產(chǎn)生，也是β細(xì)胞終末分化并分泌抗體的必需因子，在免疫調(diào)節(jié)中發(fā)揮重要做 用。
IL-1β前體在細(xì)胞內(nèi)合成后被酶剪切為成熟形態(tài)后排出到細(xì)胞外,IL-1β的前體有153個(gè)氨基酸。成熟形態(tài)有116個(gè)氨基酸。
















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