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8-羥基脫氧鳥苷/DNA/RNA Damage抗體
  • 產(chǎn)品貨號：
    BN42191R
  • 中文名稱：
    8-羥基脫氧鳥苷/DNA/RNA Damage抗體
  • 英文名稱：
    Rabbit anti-8-OHdG/DNA/RNA Damage Polyclonal antibody
  • 品牌：
    Biorigin

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  • BN42191R-100ul

    100ul

    ￥2470.00

    交叉反應(yīng)：Human(predicted:8-OHdG) 推薦應(yīng)用：IHC-P,IHC-F,IF,ELISA

產(chǎn)品描述

英文名稱8-OHdG/DNA/RNA Damage
中文名稱8-羥基脫氧鳥苷/DNA/RNA Damage抗體
別    名8 Hydroxyguanosine; 8-Hydroxy-2'-deoxyguanosine; 8-Hydroxydeoxyguanosine; 8 hydroxy 2’ deoxyguanosine; 8 hydroxyguanine; 8 hydroxyguanosine; 8 OHG; 8-OHG; 8OG; 8OHdG; 8OHG; 8 Oxoguanine; 8 hydroxyguanine; 8 Oxo 7,8 dihydroguanine; 8 oxo Gua; 8 oxoG.  



產(chǎn)品類型藥物與化合物抗體 
研究領(lǐng)域腫瘤  細胞生物  免疫學(xué)  染色質(zhì)和核信號  表觀遺傳學(xué)  Alzheimer's  
抗體來源Rabbit
克隆類型Polyclonal
產(chǎn)品應(yīng)用ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量0.283kDa
細胞定位細胞核 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated to 8-OHdG: 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹8-Hydroxydeoxyguanosine (8OHdG) is a modified base that occurs in DNA due to attack by hydroxyl radicals that are formed as byproducts and intermediates of aerobic metabolism and during oxidative stress. There is increasing evidence to support the involvement of free radical reactions in the damage of biomolecules that eventually lead to several diseases in humans, such as atherosclerosis, cerebral and heart ischemia-reperfusion injury, cancer, rheumatoid arthritis, inflammation, diabetes, aging, and neurodegenerative conditions, such as Alzheimer's disease.

Function:
Oxoguanine 8 (8-Oxoguanine) is a mutagenic oxidative damage product of guanine. Guanine is the main target for reactive oxygen species in DNA, with 8-oxoguanine being the most frequent base lesion. Thus formation of 8-oxoguanine is an important biomarker of oxidative damage to DNA. It is primarily repaired by the DNA glycosylase OGG1.

SWISS:
N/A

CAS:
3868-31-3

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

8-OHDG作為內(nèi)源性及外源性因素對DNA氧化損傷作用的生物標志物，是一個極有前途的指標，通過8-OHDG的檢測可以評估體內(nèi)氧化損傷和修復(fù)的程度，氧化應(yīng)激與DNA損傷的相互關(guān)系，對研究退行性疾病、衰老機制、癌發(fā)生機制、環(huán)境毒物與氧化應(yīng)激的關(guān)系等均有重要的意義，也可以用來評價抗氧化劑治療DNA氧化損傷的效果。已經(jīng)證實，飲食、超氧化物歧化酶、Melatonin等對8-OHDG水平具有調(diào)節(jié)作用。近期日本學(xué)者制成一種抗氧化作用雞尾酒，由葵花籽、綠茶和維生素c組成，證實了對FeC12誘導(dǎo)的8-OHDG異常增加有回調(diào)作用。隨著研究的深入，8-OHDG的應(yīng)用范圍必將越來越廣，但到目前為止，各種檢測方法都還需進一步完善，因而深入開展這項研究工作將有十分重要的實際意義。