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一氧化氮合成酶-2（誘導(dǎo)型）抗體
  • 產(chǎn)品貨號：
    BN42196R
  • 中文名稱：
    一氧化氮合成酶-2（誘導(dǎo)型）抗體
  • 英文名稱：
    Rabbit anti-iNOS Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產(chǎn)品規(guī)格

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  • BN42196R-50ul

    50ul

    ￥1486.00

    交叉反應(yīng)：Rat,Chicken(predicted:Human,Mouse,Dog,Rabbit,GuineaPig) 推薦應(yīng)用：IHC-P,IHC-F,IF,ELISA

  • BN42196R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Rat,Chicken(predicted:Human,Mouse,Dog,Rabbit,GuineaPig) 推薦應(yīng)用：IHC-P,IHC-F,IF,ELISA

  • BN42196R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Rat,Chicken(predicted:Human,Mouse,Dog,Rabbit,GuineaPig) 推薦應(yīng)用：IHC-P,IHC-F,IF,ELISA

產(chǎn)品描述

中文名稱一氧化氮合成酶-2（誘導(dǎo)型）抗體
別    名i NOS; Nitric Oxide Synthase, Inducible; HEP NOS; Hepatocyte NOS; HEPNOS; Inducible nitric oxide synthase; Inducible NO synthase; Inducible NOS; INOS; Inosl; MAC NOS; Macrophage NOS; Nitric oxide synthase 2 inducible macrophage; Nitric oxide synthase 2A (inducible hepatocytes); Nitric oxide synthase inducible; NOS 2; NOS 2A; NOS; Nos II; NOS type II; Nos2; NOS2A; NOS2_HUMAN.  




研究領(lǐng)域細(xì)胞生物  免疫學(xué)  神經(jīng)生物學(xué)  信號轉(zhuǎn)導(dǎo)  生長因子和激素  轉(zhuǎn)錄調(diào)節(jié)因子  激酶和磷酸酶  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Rat, Chicken,  (predicted: Human, Mouse, Dog, Rabbit, Guinea Pig, )
產(chǎn)品應(yīng)用ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量130kDa
細(xì)胞定位細(xì)胞漿 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from mouse NOS-2:14-100/1144 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹Nitric oxide (NO) is an inorganic, gaseous free radical that carries a variety of messages between cells. Vasorelaxation, neurotransmission and cytotoxicity can all be potentiated through cellular response to NO. NO production is mediated by members of the nitric oxide synthase (NOS) family. NOS catalyzes the oxidization of L-arginine to produce L-citrulline and NO. Two constitutive isoforms, brain or neuronal NOS (b or nNOS, type I) & endothelial cell NOS (eNOS, type III), and one inducible isoform (iNOS, type II), have been cloned. All NOS isoforms contain calmodulin, nicotinamide adenine dinucleotide phosphate (NADPH), flavin adenine dinucleotide (FAD), and flavin mononucleotide (FMN) binding domains. Nitric oxide synthase is expressed in liver, macrophages, hepatocytes, synoviocytes, stimulated glial cells and smooth muscle cells. Cytokines such as interferon-gamma (IFN), tumor necrosis factor (TNF), interleukin-1 and -2, and lipopolysaccarides (LPS) cause an increase in iNOS mRNA, protein, and activity levels. Protein kinase C-stimulating agents exhibit the same effect on iNOS activity. After cytokine induction, iNOS exhibits a delayed activity response which is then followed by a significant increase in NO production over a long period of time. Human iNOS is regulated by calcium/calmodulin (in contrast with mouse NOS2).

Function:
Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such COX2.

Subunit:
Homodimer. Binds SLC9A3R1.

Subcellular Location:
Cytosol

Tissue Specificity:
Expressed in the liver, retina, bone cells and airway epithelial cells of the lung. Not expressed in the platelets.

Similarity:
Belongs to the NOS family.
Contains 1 FAD-binding FR-type domain.
Contains 1 flavodoxin-like domain.

SWISS:
P29477

Gene ID:
4843

Database links:

Entrez Gene: 4843 Human

Entrez Gene: 18126 Mouse

Entrez Gene: 24599 Rat

Omim: 163730 Human

SwissProt: P35228 Human

SwissProt: P29477 Mouse

SwissProt: Q06518 Rat

Unigene: 709191 Human

Unigene: 2893 Mouse

Unigene: 10400 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

合成與降解（Synthesis and Degradation）
催化生物體內(nèi)一氧化氮（NO）生成的酶。分神經(jīng)型一氧化氮合成的酶（nNOS or NOS-1）、誘導(dǎo)型一氧化氮合成的酶（iNOS or NOS-2）、內(nèi)皮型一氧化氮合成的酶（eNOS or NOS-3)。






















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