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Ki67蛋白單克隆抗體
  • 產(chǎn)品貨號：
    BN42207M
  • 中文名稱：
    Ki67蛋白單克隆抗體
  • 英文名稱：
    Mouse anti-Ki-67 Monoclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產(chǎn)品規(guī)格

    售價

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  • BN42207M-50ul

    50ul

    ￥1486.00

    交叉反應：Rat,Human(predicted:Mouse) 推薦應用：IHC-P,IHC-F,Flow-Cyt

  • BN42207M-100ul

    100ul

    ￥2360.00

    交叉反應：Rat,Human(predicted:Mouse) 推薦應用：IHC-P,IHC-F,Flow-Cyt

產(chǎn)品描述

英文名稱Ki-67
中文名稱Ki67蛋白單克隆抗體
別    名Antigen identified by monoclonal antibody Ki 67; Antigen KI67; KIA; Ki67; MKI67; Proliferation related Ki 67 antigen; Antigen KI-67; KI67_HUMAN.  
研究領域腫瘤  細胞生物  神經(jīng)生物學  細胞周期蛋白  細胞分化  細胞類型標志物  表觀遺傳學  
抗體來源Mouse
克隆類型Monoclonal
克 隆 號6B9
交叉反應Human, Rat,  (predicted: Mouse, )
產(chǎn)品應用IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100 IF=1:100-500 （石蠟切片需做抗原修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量358kDa
細胞定位細胞核 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human Ki-67: 
亞    型IgG
純化方法affinity purified by Protein G
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹Ki67 antigen is the prototypic cell cycle related nuclear protein, expressed by proliferating cells in all phases of the active cell cycle (G1, S, G2 and M phase). It is absent in resting (G0) cells. Ki67 antibodies are useful in establishing the cell growing fraction in neoplasms (immunohistochemically quantified by determining the number of Ki67 positive cells among the total number of resting cells = Ki67 index). In neoplastic tissues the prognostic value is comparable to the tritiated thymidine labelling index. The correlation between low Ki67 index and histologically low grade tumours is strong. Ki67 is routinely used as a neuronal marker of cell cycling and proliferation.

Function:
Thought to be required for maintaining cell proliferation.

Subcellular Location:
Nucleus. Chromosome. Predominantly localized in the G1 phase in the perinucleolar region, in the later phases it is also detected throughout the nuclear interior, being predominantly localized in the nuclear matrix. In mitosis, it is present on all chromosomes.

Similarity:
Contains 1 FHA domain.

SWISS:
P46013

Gene ID:
4288

Database links:
Entrez Gene: 4288 Human

Entrez Gene: 17345 Mouse

Entrez Gene: 246042 Rat

Omim: 176741 Human

SwissProt: P46013 Human

SwissProt: Q91VE6 Mouse

SwissProt: Q5RJM0 Rat

Unigene: 689823 Human

Unigene: 80976 Human

Unigene: 4078 Mouse

Unigene: 233802 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

細胞增殖標志物(Proliferation Marker)
Ki67與PCNA一樣，為細胞增殖的一種標記，在細胞凋亡中S、G2 、M期均有表達，G0期缺如。 Ki-67增殖指數(shù)高低與許多腫瘤的分化程度、浸潤、轉移以及預后密切相關，因此被廣泛作為各種惡性腫瘤的必檢項目之一。